B. Härtel, J-H. Graubaum and B. Schneider: Ernährungsumschau, 1993; 40(4): 152-155.
Objectives. To determine whether giving aqueous solutions of the intense sweeteners aspartame, acesulfame-k, cyclamate and saccharin to healthy subjects would influence the secretion of insulin which could result in changes in the level of blood sugar.
Methods. 14 healthy subjects were included in the study test group which consisted of eight women and six men aged between 19 and 52. The study was performed over a period of 18 days. The six test solutions were given to the subjects using a pattern of multiple crossover design.
Results. The concentrations of plasma insulin and blood glucose did not vary significantly from the normal range at any measurement time following ingestion of either the water control or any of the four different sweetener solutions.
Conclusions. This study showed that there was no difference in the levels of blood glucose in persons having consumed a low-calorie sweetened beverage and those who consumed water.