Sucrose compared with artificial sweeteners: different effects on ad libitum food intake and body weight after 10wk of supplementation in overweight subjects.
Anne Raben, Tatjana H Vasilaras, A Christina MØller, and Arne Astrup
Background: The role of artificial sweeteners in body-weight regulation is still unclear.
Objective: We investigated the effect of long-term
supplementation with drinks and foods containing either sucrose or artificial
sweeteners on ad libitum food intake and body weight in over-weight subjects.
Design: For 10 wk, overweight men and women consumed
daily supplements of either sucrose [n
= 21, body mass index (BMI; in kg/m2) = 28.0] or artificial
sweeteners (n=20, BMI = 27.6). On
average, sucrose supplements provided 3.4 MJ and 152g sucrose/d and sweetener
supplements provided 1.0 MJ and 0g sucrose/d.
Results: After 10wk, the sucrose group had increased
in total energy (by 1.6 MJ/d), sucrose (to 28% of energy), and carbohydrate
intakes and decreases in fat and protein intakes. The sweetener group had small but significant
decreases in sucrose intake and energy density. Body
weight and fat mass increased in the sucrose group (by 1.6 and 1.3
kg respectively) and decreased in the sweetener group (by 1.0 and 0.3 kg respectively);
the between-group differences were significant at P< 0.001
and P< 0.01 (fat mass). Systolic and
diastolic blood pressure increased in the sucrose group (by 3.8 and 4.1 mm Hg,
respectively) and decreased in the sweetener group (by 3.1 and 1.2 mm Hg
Conclusions: Overweight subjects who consumed fairly large
amounts of sucrose (28% of energy) mostly as beverages, had increased energy
intake, body weight, fat mass and blood pressure after 10 wk.
These effects were not observed in a similar
group of subjects who consumed artificial sweeteners.
Am J Clin Nutr 2002; 76: 721-9